Catheter Associated Urinary Tract Infections (CAUTIs)
Urinary tract infections are the most common type of healthcare-associated infection, accounting for more than 30% of infections reported by acute care hospitals. Catheter-associated urinary tract infections (CAUTI) has been associated with increased morbidity, mortality, hospital cost, and length of stay. In addition, bacteriuria commonly leads to unnecessary antimicrobial use, and urinary drainage systems are often reservoirs for multidrug-resistant bacteria and a source of transmission to other patients.
Biofilms on Urological Medical Devices
The lumens of a urinary (Foley) catheter can be overrun with mineral-rich biofilms formed in the presence of urease-producing bacteria such as Proteus mirabilis. Urea, a waste product excreted by the kidneys when you urinate, is hydrolysed in the presence of urease, an enzyme produced by some bacteria. The hydrolysis product of urea is ammonia. Ammonia in the lumen effectively increases the pH of the urine stream thus precipitating otherwise soluble polyvalent calcium phosphate carbonate salts. This precipitation into the lumen entraps the bacteria which grow into biofilm thus further occluding the flow of urine and creating a dangerous situation for the infected patient.
Patented Pre-Clinical Platforms
Our solutions are broadly bactericidal and fungicidal and can be incorporated into an array of materials for the production of antimicrobial medical devices.